| view 👀:6 |
🙍 oneddl |
redaktor: book24h | Rating👍:
Phenotyping of Human iPSC-derived Neurons Patient-Driven Research [#473592]
English | 2022 | ISBN: 0128222778 | 374 pages | True PDF EPUB | 44.88 MB
Phenotyping of Human iPSC-derived Neurons: Patient-Driven Research examines the steps in a preclinical pipeline that utilizes iPSC-derived neuronal technology to better understand neurological disorders and identify novel therapeutics, also providing considerations and best practices. By presenting example projects that identify phenotypes and mechanisms relevant to autism spectrum disorder and epilepsy, this book allows readers to understand what considerations are important to assess at the start of project design. Sections address reproducibility issues and advances in technology at each stage of the pipeline and provide suggestions for improvement. From patient sample collection and proper controls to neuronal differentiation, phenotyping, screening, and considerations for moving to the clinic, these detailed descriptions of each stage of the pipeline will help everyone, regardless of stage in the pipeline.
In recent years, drug discovery in the neurosciences has struggled to identify novel therapeutics for patients with varying indications, including epilepsy, chronic pain, and psychosis. Current treatment options for such patients are decades old and offer little relief with many side effects. One explanation for this lull in novel therapeutics is a lack of novel target identification for neurological disorders (and target identification requires exemplar preclinical data). To improve on the preclinical work that often relies on rodent modeling, the field has begun utilizing patient-derived induced pluripotent stem cells (iPSCs) to differentiate neurons in vitro for preclinical characterization of neurological disease and target identification.
Discusses techniques and new technology for iPSC culturing and neuronal differentiation to establish best practices in the labOutlines considerations for phenotypic assay developmentProvides information about the successes, failures, and implications of phenotyping and screening with iPSC-derived neuronsDescribes how human iPSC-derived neurons are being used for preclinical discovery research as well as the development of therapeutics utilizing hiPSC-derived neurons
https://rapidgator.net/file/9f75990a527d0be9ca863ec46deb62f7/jdiiz.P.o.H.i.N.P.R.rar.html
Please Help Me Click Connect Icon Below Here and Share News to Social Network | Thanks you !
⚠️ Dead Link ?
You may submit a re-upload request using the search feature.
All requests are reviewed in accordance with our Content Policy.
Significant surge in the popularity of free ebook download platforms. These virtual repositories offer an unparalleled range, covering genres that span from classic literature to contemporary non-fiction, and everything in between. Enthusiasts of reading can easily indulge in their passion by accessing free books download online services, which provide instant access to a wealth of knowledge and stories without the physical constraints of space or the financial burden of purchasing hardcover editions.
Comments (0)
Users of Guests are not allowed to comment this publication.